6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells
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منابع مشابه
6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells
BACKGROUND The antimetabolite 6-thioguanine (6-TG) has been used to treat both human and canine lymphoid malignancies. 6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell line, causing downregulation of DNA methyltransferase 1 (DNMT1) through ubiquitin-targeted degradation. Zebularine (Zeb), a similar cytidine analog, also has demethylating activity...
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ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2014
ISSN: 1746-6148
DOI: 10.1186/s12917-014-0290-8